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Kenichi Sugihara Selected Research

Tegafur

1/2020S-1 and Oxaliplatin Versus Tegafur-uracil and Leucovorin as Postoperative Adjuvant Chemotherapy in Patients With High-risk Stage III Colon Cancer (ACTS-CC 02): A Randomized, Open-label, Multicenter, Phase III Superiority Trial.
1/2019Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial.
1/2018Planned Safety Analysis of the ACTS-CC 02 Trial: A Randomized Phase III Trial of S-1 With Oxaliplatin Versus Tegafur and Uracil With Leucovorin as Adjuvant Chemotherapy for High-Risk Stage III Colon Cancer.
1/2018Updated 5-year survival and exploratory T x N subset analyses of ACTS-CC trial: a randomised controlled trial of S-1 versus tegafur-uracil/leucovorin as adjuvant chemotherapy for stage III colon cancer.
1/2018A randomised-controlled trial of 1-year adjuvant chemotherapy with oral tegafur-uracil versus surgery alone in stage II colon cancer: SACURA trial.
3/2016Genome-wide DNA Copy-number Analysis in ACTS-CC Trial of Adjuvant Chemotherapy for Stage III Colonic Cancer.
7/2012Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer.
9/2010Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study).
2/2003Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.

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Kenichi Sugihara Research Topics

Disease

122Neoplasms (Cancer)
08/2022 - 01/2002
90Colorectal Neoplasms (Colorectal Cancer)
11/2021 - 05/2002
70Neoplasm Metastasis (Metastasis)
06/2022 - 07/2002
47Colonic Neoplasms (Colon Cancer)
06/2022 - 12/2003
32Stomach Neoplasms (Stomach Cancer)
12/2015 - 10/2004
26Rectal Neoplasms (Rectal Cancer)
06/2022 - 06/2003
22Breast Neoplasms (Breast Cancer)
09/2016 - 03/2005
21Lymphatic Metastasis
08/2022 - 01/2002
13Adenocarcinoma
08/2020 - 10/2003
10Carcinogenesis
01/2017 - 05/2002
8Carcinoma (Carcinomatosis)
01/2010 - 01/2002
7Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
06/2017 - 09/2002
5Hemorrhage
10/2014 - 11/2013
4Microsatellite Instability
12/2020 - 10/2006
4Anastomotic Leak
03/2020 - 12/2013
4Liver Diseases (Liver Disease)
11/2012 - 11/2009
3Neutropenia
08/2020 - 09/2013
3Pneumonia (Pneumonitis)
01/2017 - 06/2013
3Weight Loss (Weight Reduction)
08/2015 - 04/2014
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2014 - 04/2007
3Chronic Obstructive Pulmonary Disease (COPD)
08/2014 - 06/2013
3Adenoma (Adenomas)
12/2003 - 09/2002
2Mucinous Adenocarcinoma (Mucinous Carcinoma)
10/2020 - 10/2003
2Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
01/2018 - 11/2010
2Aggressive Fibromatosis (Desmoid)
08/2016 - 11/2014
2Noninfiltrating Intraductal Carcinoma (DCIS)
05/2016 - 12/2012
2Margins of Excision
05/2016 - 10/2003
2Peritonitis
01/2016 - 10/2015

Drug/Important Bio-Agent (IBA)

26Messenger RNA (mRNA)IBA
01/2017 - 01/2002
20Fluorouracil (Carac)FDA LinkGeneric
08/2020 - 11/2003
17Leucovorin (Folinic Acid)FDA Link
08/2020 - 02/2003
14Bevacizumab (Avastin)FDA Link
08/2020 - 10/2008
14Oxaliplatin (Eloxatin)FDA LinkGeneric
08/2020 - 12/2008
14Proteins (Proteins, Gene)FDA Link
09/2016 - 06/2003
11Carcinoembryonic AntigenIBA
01/2021 - 06/2003
10Biomarkers (Surrogate Marker)IBA
10/2020 - 05/2008
10Cyclooxygenase 2 (Cyclooxygenase-2)IBA
04/2009 - 05/2002
9Cetuximab (Erbitux)FDA Link
06/2022 - 11/2009
9TegafurIBA
01/2020 - 02/2003
8Irinotecan (Camptosar)FDA LinkGeneric
01/2015 - 11/2003
7UracilIBA
01/2020 - 02/2003
7Capecitabine (Xeloda)FDA Link
06/2017 - 11/2011
6Biological ProductsIBA
01/2022 - 12/2002
6Hormones (Hormone)IBA
05/2016 - 12/2005
6DNA (Deoxyribonucleic Acid)IBA
03/2016 - 09/2005
6Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA
01/2015 - 07/2002
6Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2009 - 03/2005
5Calcibiotic Root Canal SealerIBA
01/2021 - 09/2005
5Pharmaceutical PreparationsIBA
11/2014 - 06/2005
4Indicators and Reagents (Reagents)IBA
10/2020 - 12/2004
4Panitumumab (Vectibix)FDA Link
11/2014 - 12/2012
4Estrogen ReceptorsIBA
11/2013 - 03/2005
4Paclitaxel (Taxol)FDA LinkGeneric
11/2013 - 11/2009
4ErbB Receptors (EGF Receptor)IBA
11/2013 - 12/2008
4EnzymesIBA
03/2013 - 06/2003
4RNA (Ribonucleic Acid)IBA
06/2012 - 12/2008
4DecitabineFDA Link
03/2012 - 01/2005
4ParaffinIBA
04/2009 - 01/2003
4Formaldehyde (Formol)FDA Link
04/2009 - 01/2003
4Thymidylate SynthaseIBA
07/2008 - 02/2003
4Thymidine PhosphorylaseIBA
07/2008 - 05/2004
4Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
09/2007 - 10/2003
3Therapeutic UsesIBA
07/2021 - 01/2004
3AntigensIBA
01/2016 - 12/2003
3Phosphotransferases (Kinase)IBA
10/2015 - 06/2013
3Serum AlbuminIBA
08/2015 - 01/2013
3Zoledronic Acid (Zometa)FDA Link
11/2013 - 11/2012
3Tumor Biomarkers (Tumor Markers)IBA
11/2013 - 01/2007
3Trastuzumab (Herceptin)FDA Link
11/2012 - 11/2011
3MicroRNAs (MicroRNA)IBA
06/2012 - 04/2008
3Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
12/2004 - 10/2003
2CarbohydratesIBA
11/2020 - 01/2016
2regorafenibIBA
01/2019 - 01/2018
2titanium silicide (TS-1)IBA
01/2018 - 03/2016
2KinesinsIBA
09/2016 - 12/2011
2Alkaline PhosphataseIBA
08/2015 - 12/2014
2CreatinineIBA
08/2015 - 04/2014
2tyrosine receptor (receptor, tyrosine)IBA
07/2015 - 06/2013
2ErythropoietinFDA Link
07/2015 - 06/2013

Therapy/Procedure

59Drug Therapy (Chemotherapy)
06/2022 - 07/2002
44Therapeutics
07/2021 - 06/2003
26Adjuvant Chemotherapy
01/2021 - 01/2004
25Lymph Node Excision (Lymph Node Dissection)
08/2022 - 10/2009
25Gastrectomy
01/2016 - 10/2004
17Colectomy
01/2022 - 09/2004
11Hepatectomy
11/2020 - 10/2003
9Lasers (Laser)
06/2012 - 06/2005
7Radiotherapy
03/2022 - 11/2011
6Operative Surgical Procedures
08/2022 - 11/2010
6Chemoradiotherapy
07/2021 - 03/2013
5Restorative Proctocolectomy
06/2017 - 01/2014
4Proctectomy
06/2022 - 11/2009
4Ligation
11/2021 - 01/2011
3Hyperthermic Intraperitoneal Chemotherapy
03/2021 - 01/2010
3Laparotomy
01/2021 - 11/2003
3Activities of Daily Living (ADL)
08/2015 - 04/2014
3Colostomy
11/2013 - 11/2010
2Combined Modality Therapy
09/2016 - 11/2013
2Metastasectomy
09/2016 - 11/2010
2Esophagectomy
01/2016 - 07/2012